People with high blood sugar take Diabetes medication to lower blood sugar levels.
There is a universal consensus on the following:
The 10-year risk of cardiovascular diseases in the diabetic population is 2% higher than in the non-diabetic population.
The lifetime risk of dialysis in case of a diabetic patient is just 1.5% higher than the normal population.
The lifetime risk of blindness is 4% higher in the case of diabetes patients.
All the clinical studies specifically done on PIMA Indians (population with the highest rate of Diabetes) make it clear that high blood sugar increases the risk of Cardio Vascular Disease, Retinopathy, Neuropathy and Nephropathy.
Higher blood sugar = higher risk of diseases.
In other words
Lower blood sugar = lower risk of diseases.
But, does that also mean lowering blood sugar with Diabetes medication = lower risk of diseases.
It may seem obvious, but it is not so.
Given below is the meta-analysis of 13 Randomized Control Trial (RCT) – 9500 Metformin cases / 3500 for 5 years (PLOS Medicine-2012). It can be seen that the Risk Ratio Interpretation (RRI) for all the risk factors increase among patients on Metformin.
|Cardiovascular disease mortality||1.05|
It means that by taking Metformin, one can lower blood sugar.
A large study called ADOPT (A Diabetes Outcome Progression Trial) blinded RCT (Randomized Controlled Trial) in which 4360 patients were followed up to 4 years to compare the effects of Glyburide, Metformin, and Rosiglitazone.
|Class of Drug||Mortality Rate %||Edema %||Weight Gain %|
There are other classes of Diabetes medication such as GLPS, Meglitinides, and SGLT2. The most relevant research paper is
Boussageon R1, Gueyffier F2, Cornu C3.
In 2013, the level of evidence for the clinical efficacy of antidiabetic drugs is disappointing and does not support the millions of prescriptions being written for them.
All these reports conclude that although high blood sugar may be bad for you, lowering the level of blood sugar with Diabetes medication is worst for your health and also your wealth.
We must, therefore, understand that Diabetes or high blood sugar itself is not a disease, but a risk factor for various diseases.